Does It MEK a Difference? Understanding Immune Effects of Targeted Therapy.
نویسندگان
چکیده
BRAF inhibitor (BRAFi) treatment enhances antitumor immunity, but is associated with increased intratumoral PD-L1 expression. MEK inhibitors (MEKi) may alter T-cell function; however, recent studies demonstrate preserved T-cell infiltrate during treatment with BRAFi/MEKi. These data have important implications for combining BRAFi/MEKi and checkpoint blockade in the treatment of melanoma.
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عنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 21 14 شماره
صفحات -
تاریخ انتشار 2015